| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8148 | Biomaterials | 2010 | 7 Pages |
Abstract
Cell–cell cooperativity in populations of motile and transiently interacting immune cells has been difficult to assess in the absence of tools to control proximity and communication. Here, we describe the generation of cell-laden microwells that can precisely control contact-mediated interactions and multicellular ‘quorum’ decisions in lymphocytes. Different types of fate decisions for activating T cells can be shown to variously obey ‘binary’ or ‘density’ outcomes, correlated with cell–cell contact, using this new platform.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Junsang Doh, Miju Kim, Matthew F. Krummel,