Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8258367 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2018 | 45 Pages |
Abstract
Drosophila melanogaster has been a key model in developing our current understanding of the molecular mechanisms of ageing. Of particular note is its role in establishing the evolutionary conservation of reduced insulin and IGF-1-like signaling in promoting healthy ageing. Capitalizing on its many advantages for experimentation, more recent work has revealed how precise nutritional and genetic interventions can improve fly lifespan without obvious detrimental side effects. We give a brief summary of these recent findings as well as examples of how they may modify ageing via actions in the gut and muscle. These discoveries highlight how expanding our understanding of metabolic and signaling interconnections will provide even greater insight into how these benefits may be harnessed for anti-ageing interventions.
Keywords
AMPKIISFKH4EBPILPETsTSCERKmTORORFGCNAOPE-twenty sixTORATF4PI3KAMP activated protein kinaseC/EBP homologous proteineIFROSCHOPAgeingInsulin signalingeukaryotic translation initiation factorFoxOphosphoinositide 3-kinaseactivating transcription factor 4open reading framedietary restrictioncalorie restrictionDrosophilaMechanistic target of rapamycinInsulin-like peptideforkheadTuberous sclerosis complexextracellular signal-regulated kinaseReactive oxygen species
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Matthew D.W. Piper, Linda Partridge,