Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8262163 | Experimental Gerontology | 2018 | 4 Pages |
Abstract
Ageing and atherosclerosis are associated with oxidative stress. Mitochondrial redox function declines with ageing. Here we tested whether ageing LDL receptor knockout mice (LDLrâ/â) develop spontaneous atherosclerosis and whether mitochondrial reactive oxygen species (mtROS) correlate with atherosclerosis. Compared with young mice, aged LDLrâ/â mice exhibited 20-fold larger aortic lesion size, although the plasma cholesterol levels did not vary between age groups. The lesion sizes increased exponentially from 3 to 24 months of age (r = 0.92, p = 0.0001) and were correlated with mtROS across the age range (r = 0.81, p = 0.0001). Thus, LDLrâ/â mice develop spontaneous diet-independent atherosclerosis, that advances exponentially with ageing. We propose that age related increases in mtROS contribute to accelerate atherosclerosis development in hypercholesterolemic mice.
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Authors
Gabriel G. Dorighello, Bruno A. Paim, Ana Catarina R. Leite, Anibal E. Vercesi, Helena C.F. Oliveira,