Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8262169 | Experimental Gerontology | 2018 | 8 Pages |
Abstract
The findings demonstrate that, like humans, the Drosophila heart develops a fibrosis-like phenotype as it ages. Although having no gross impact on collagen accumulation, reduced SPARC expression extended Drosophila lifespan and cardiac health span. It is proposed that cardiac fibrosis in humans may develop due to the activation of conserved mechanisms and that SPARC may mediate cardiac ageing by mechanisms more subtle than gross accumulation of collagen.
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Leigh Vaughan, Richard Marley, Sara Miellet, Paul S. Hartley,