Article ID Journal Published Year Pages File Type
8262169 Experimental Gerontology 2018 8 Pages PDF
Abstract
The findings demonstrate that, like humans, the Drosophila heart develops a fibrosis-like phenotype as it ages. Although having no gross impact on collagen accumulation, reduced SPARC expression extended Drosophila lifespan and cardiac health span. It is proposed that cardiac fibrosis in humans may develop due to the activation of conserved mechanisms and that SPARC may mediate cardiac ageing by mechanisms more subtle than gross accumulation of collagen.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Authors
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