| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8262277 | Experimental Gerontology | 2018 | 9 Pages |
Abstract
Ca2+ dysregulation, mainly the SR Ca2+ store, in CSM is more pronounced in lean old swine, which is indicative of mild, proliferative CAD. MetS old and MetS young swine exhibit Ca2+ dysfunction that is typical of late, severe disease. The more advanced, complex plaques in MetS old swine suggest that the “aging milieu” potentiates effects of Ca2+ handling dysfunction in CAD.
Keywords
CFXIELCACEELCSMCircumflex arteryivGTTIVUS[Ca2+]iintravenous glucose tolerance testcoronary artery diseaseMetabolic syndromeintravascular ultrasoundCADmean arterial pressureSERCALADexternal elastic laminainternal elastic laminaMETSmapleft anterior descending arteryCoronary artery calcificationintracellular free calcium
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Ageing
Authors
Jill K. Badin, Rebecca S. Bruning, Michael Sturek,