Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8262308 | Experimental Gerontology | 2018 | 30 Pages |
Abstract
Skeletal muscle aging is associated with loss of mass, function, and strength-a condition known as sarcopenia. It has been reported that sarcopenia can be attenuated by physical exercise. Therefore, we investigated whether 2 different physical exercise protocols could modulate and induce changes in oxidative and inflammatory parameters, as well as in BDNF and DNA repair enzyme levels in skeletal muscle tissue of aged rats. Aging Wistar rats performed treadmill or strength training for 50â¯min 3 to 4 times a week for 8â¯weeks. Strength training decreased 2â²,7â²-dichlorofluorescein (DCFH) oxidation (Pâ¯=â¯0.0062); however, nitric oxide, protein deglycase DJ-1, and tumor necrosis factor alpha (TNF-α) levels increased after aerobic training (Pâ¯=â¯0.04, Pâ¯=â¯0.027 and Pâ¯=â¯0.009, respectively). Both exercise protocols increased superoxide dismutase (SOD) and catalase (CAT) activity (Pâ¯=â¯0.0017 and Pâ¯=â¯0.0326) whereas the activity of glutathione (GSH) (Pâ¯=â¯0.0001) was decreased. Brain-derived neurotropic factor (BDNF) levels were not affected by exercise, but 8-oxoguanine glycosylase (OGG1) decreased after strength training (Pâ¯=â¯0.0007). In conclusion, oxidative parameters showed that skeletal muscle adapt to increased ROS levels, reducing the risk of free radical damage to the tissue after both exercise protocols. These results show that the effects of physical exercise on skeletal muscle are mediated in an exercise type-dependent manner.
Related Topics
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Thais Ceresér Vilela, Pauline Souza Effting, Giulia dos Santos Pedroso, Hemelin Farias, Lara Paganini, Helen Rebelo Sorato, Renata Tiescoski Nesi, Vanessa Moraes de Andrade, Ricardo Aurino de Pinho,