Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8262420 | Experimental Gerontology | 2018 | 9 Pages |
Abstract
This prospective study aimed to address changes in inflammatory response between different aged populations of patients who sustained burn and inhalation injury. Plasma and bronchoalveolar lavage (BAL) samples were collected from 104 patients within 15 h of their estimated time of burn injury. Clinical variables, laboratory parameters, and immune mediator profiles were examined in association with clinical outcomes. Older patients were at higher odds for death after burn injury (odds ratio (OR) = 7.37 per 10 years, p = 0.004). In plasma collected within 15 h after burn injury, significant increases in the concentrations of interleukin 1 receptor antagonist (IL-1RA), interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 6 (IL-6), granulocyte colony-stimulating factor (G-CSF), interferon-gamma-induced protein 10 (IP-10) and monocyte chemoattractant protein 1 (MCP-1) (p < 0.05 for all) were observed in the â¥Â 65 group. In the BAL fluid, MCP-1 was increased three-fold in the â¥Â 65 group. This study suggests that changes in certain immune mediators were present in the older cohort, in association with in-hospital mortality.
Keywords
IL-1RA%TBSACOHbIL-13IL-12IP-10IL-8IL-17GM-CSFIL-2IFN-γIL-10IL-1βBALIL-6MCP-1IL-4ROCCarboxyhemoglobinAUCInhalation injuryInterleukin 1 receptor antagonistinflammationinterferon-gammainterleukin 1 betaInterleukin 10interleukin 12interleukin 13interleukin 17interleukin 2Interleukin 4interleukin 6Interleukin 8intensive care unitICUtumor necrosis factor alphaAgingBurngranulocyte-macrophage colony-stimulating factorgranulocyte colony-stimulating factorG-CSFTNF-αbronchoalveolar lavagearea under the curveodds ratioImmune mediatorsreceiver operating characteristicsmonocyte chemoattractant protein 1
Related Topics
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
John H. Frankel, Devin M. Boe, Joslyn M. Albright, Eileen B. O'Halloran, Stewart R. Carter, Christopher S. Davis, Luis Ramirez, Ellen L. Burnham, Richard L. Gamelli, Majid Afshar, Elizabeth J. Kovacs,