| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8262862 | Experimental Gerontology | 2016 | 8 Pages |
Abstract
Our findings reveal an age-dependent reduction of AIM2 expression and activation which may explain reduced cytokine responses to the cytosolic DNA mimic poly(dA:dT) in healthy elderly individuals. Reduced AIM2-mediated sensing with age may contribute to increased vulnerability to bacterial or viral infections in the elderly.
Keywords
PAMPsPRRsAIM2pNPPRLRsWBCCLRsESRNLRsPBMCWBAp-nitrophenyl phosphateTLRsWhole blood assaypathogen-associated molecular patternsHumanInnate immunityAgingerythrocyte sedimentation rateperipheral blood mononuclear cellscytomegalovirusCMVHealthy participantsabsent in melanoma 2C-reactive proteinCRPNOD-like receptorspattern recognition receptorsC-type lectin receptorsToll-like receptors
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Qi Wang, Johanna Westra, Kornelis S.M. van der Geest, Jill Moser, Johan Bijzet, Timara Kuiper, Pedro G. Lorencetti, Leo A.B. Joosten, Mihai G. Netea, Peter Heeringa, Elisabeth Brouwer, Annemieke M.H. Boots,