Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8262985 | Experimental Gerontology | 2015 | 27 Pages |
Abstract
In summary, the results of the present work reveal the existence of a transcriptomic component that shows progressive expression changes associated to age in peripheral blood leukocytes, highlighting both the dynamic nature of the process and the need to complement young vs. elder studies with longitudinal studies that include middle aged individuals. From the transcriptional point of view, immunosenescence seems to be occurring from a relatively early age, at least from the late 20s/early 30s, and the 49-56Â year old age-range appears to be critical. In general, the genes that, according to our results, show progressive expression changes with aging are involved in pathogenic/cellular processes that have classically been linked to aging in humans: cancer, immune processes and cellular growth vs. maintenance.
Related Topics
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Haritz Irizar, JoaquÃn Goñi, Ainhoa Alzualde, Tamara Castillo-Triviño, Javier Olascoaga, Adolfo Lopez de Munain, David Otaegui,