Article ID Journal Published Year Pages File Type
8263397 Experimental Gerontology 2015 11 Pages PDF
Abstract
This study investigated the effects of resistance training (RT) on the metabolism of testosterone (T) in younger (n = 5, 28 ± 3 yrs.) and older (n = 8, 70 ± 2 yrs.) men. Experimental heavy resistance exercises (5 × 10RM leg presses) were performed before and after a 12-month of RT. No age differences were found in the production or metabolic clearance rate of T (determined by stable isotope dilution method), skeletal muscle androgen receptor content or serum LH concentrations due to acute or chronic RT. The T production capacity response to gonadotropin stimulation and the concentrations of the urinary T metabolites (androsterone and etiocholanolone) were lower in the older compared to younger men (p < 0.05-0.01). This study further showed that RT may have acute effect on T production and clearance rates, while the exercise-induced increases in serum T appeared to be induced by decreased metabolic clearance rate of T. Attenuated T production capacity and urinary excretion of T metabolites in older men may reflect the known reduction in testicular steroidogenesis upon aging. No changes were observed in T metabolism due to RT indicating a homeostatic stability for this hormone in men of different ages.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
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