| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8263790 | Experimental Gerontology | 2015 | 9 Pages |
Abstract
Advancing donor age reduces the potential of adipose-derived SVF to derive a mature microcirculation, but does not hinder initial angiogenesis. However, modulation of Thbs-1 may improve this outcome. This data suggests that greater pruning, dysfunctional structural adaptation and/or poor maturation with initiation of blood flow may occur in oSVF.
Keywords
ADSCPDGFβTNFTie1Angpt2InosculationSVFPVDTGFβ1ANGPTL4HGFCXCL5BMSCangiopoietin-2DAPIMSCDEX4′,6-diamidino-2-phenylindoleangiopoietin-like 4AngiogenesisIschemiaImmunohistochemistryIHCVascular remodelingMaturationPeripheral vascular diseasetransforming growth factor beta 1Terminal deoxynucleotidyl transferase dUTP nick end labelingThrombospondin-1TUNELApoptosisconditioned mediaAgingAdipose-derived stromal cellsMesenchymal stem cellthree dimensionalHepatocyte growth factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)tumor necrosis factorStromal vascular fraction
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Allison L. Aird, Christopher D. Nevitt, Katelyn Christian, Stuart K. Williams, James B. Hoying, Amanda J. LeBlanc,