Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8264084 | Experimental Gerontology | 2014 | 9 Pages |
Abstract
The midlife-initiated 4-mo running program triggered multiple responses within the mouse brain cortex, through the activation of anti-amyloidogenic, pro-survival, synaptogenic and neuroprotective pathways. However, most of the beneficial actions of the exercise regimen appeared only after 4Â months, since 2-mo-exercised mice showed marked impairments of the endpoints we considered. This could imply that a midlife-initiated regimen of moderate treadmill running may require an adequate time lag to activate beneficial compensative mechanisms within the mouse brain cortex.
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Authors
Silvia Di Loreto, Stefano Falone, Antonella D'Alessandro, Silvano Jr., Pierluigi Sebastiani, Marisa Cacchio, Fernanda Amicarelli,