| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8264293 | Experimental Gerontology | 2014 | 7 Pages |
Abstract
Activation of BKCa channels is critically involved in forskolin induced cardioprotection. The age-dependency of forskolin induced cardioprotection is not caused by age-dependent differences in PKA activation. Pharmacological targeting of BKCa channels before or after myocardial ischemia is a promising therapeutic strategy to protect the aged heart from ischemia and reperfusion injury.
Keywords
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Andre Heinen, Martin Ströthoff, Anika Schmidt, Nadine Stracke, Friederike Behmenburg, Inge Bauer, Markus W. Hollmann, Ragnar Huhn,