Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8264390 | Experimental Gerontology | 2014 | 11 Pages |
Abstract
This scenario is expected to be even more clarified in the next future with the use of next generation sequencing (NGS) techniques, which are becoming applicable to evaluate mtDNA variability and, then, new mathematical/bioinformatic analysis methods are urgently needed. Recent advances of association studies on age-related diseases and mtDNA variability will also be discussed in this review, taking into account the bias hidden by population stratification. Finally, very recent findings in terms of mtDNA heteroplasmy (i.e. the coexistence of wild type and mutated copies of mtDNA) and aging as well as mitochondrial epigenetic mechanisms will also be discussed.
Keywords
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Federica Sevini, Cristina Giuliani, Dario Vianello, Enrico Giampieri, Aurelia Santoro, Fiammetta Biondi, Paolo Garagnani, Giuseppe Passarino, Donata Luiselli, Miriam Capri, Claudio Franceschi, Stefano Salvioli,