| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8264436 | Experimental Gerontology | 2014 | 6 Pages |
Abstract
Aging is associated with a progressive decline in T cell function, chronic inflammation, hyperimmunoglobulinemia, autoimmunity, poor response to vaccines, and increased susceptibility to infection as well as diseases associated with chronic inflammation. DCs in aging appear to be functionally impaired with regard to response to uptake of antigens, phagocytosis of apoptotic cells, migration, priming of CD4Â + and CD8Â + T cells, and production of IFN-I and IFN-III. In this review I have discussed various mechanisms, which may be responsible for impaired functions of DCs.
Keywords
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Sudhir Gupta,