Article ID Journal Published Year Pages File Type
8264715 Experimental Gerontology 2014 8 Pages PDF
Abstract
We demonstrated that the proportion of Th17 cells increased in the aged mice both in naïve and memory cell populations. Elevation of IL-1R and IL-1β expression and the reduction in IL-2 and IL-2R expression in aged mice seemed to promote Th17 differentiation. Our results suggest that enhanced Th17 differentiation in aging may have a pathogenic role in the development of Th17-mediated autoimmune diseases.
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Authors
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