Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8264715 | Experimental Gerontology | 2014 | 8 Pages |
Abstract
We demonstrated that the proportion of Th17 cells increased in the aged mice both in naïve and memory cell populations. Elevation of IL-1R and IL-1β expression and the reduction in IL-2 and IL-2R expression in aged mice seemed to promote Th17 differentiation. Our results suggest that enhanced Th17 differentiation in aging may have a pathogenic role in the development of Th17-mediated autoimmune diseases.
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Mi-Ae Lim, Jennifer Lee, Jin-Sil Park, Joo-Yeon Jhun, Young-Mi Moon, Mi-La Cho, Ho-Youn Kim,