| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8264867 | Experimental Gerontology | 2010 | 6 Pages |
Abstract
Building on these results, we examined the expression of VDAC-1 in an in vitro model of excitotoxicity. We show that glutamate-induced calcium toxicity in neurons induces changes of voltage-dependent anion channel 1 related to downstream events of mitochondrial apoptosis like poly-ADP-ribosylation.
Keywords
HRPNMDAMPTPHspVDACHUVECEGMtBHPBBEhEGFAgeing modelPARP-1FBSN-methyl-d-aspartateLongevityMALDI–TOFMitochondrial apoptosismitochondrial permeability transition poreAlzheimer’s diseaseParkinson’s diseaseESCSystems biologyfetal bovine serumHuman umbilical vein endothelial cellsEmbryonic stem cellstertiary butylhydroperoxideendothelial growth mediumQuantitative proteomicsHeat shock proteinvoltage-dependent anion channelVoltage-dependent anion channel 1
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Karlfried Groebe, Martina Klemm-Manns, Gerhard P. Schwall, Heiko Hübenthal, Herrmann Unterluggauer, Pidder Jansen-Dürr, Robert M. Tanguay, Geneviève Morrow, André Schrattenholz,