The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus

Article ID	Journal	Published Year	Pages	File Type
8286708	Redox Biology	2018	12 Pages	PDF

Keywords

SCV BSH NADPH DTT IPTG N-ethylmaleimide MHQ ADH AldA NaOCl HOCl 5-bromo-4-chloro-3-indolyl-β-d-galactopyranoside X-Gal RES CFU RCS MPO ROS Hydrogen peroxide aldehyde dehydrogenase EDTA Ethylenediaminetetraacetic acid Staphylococcus aureus MRSA methicillin-resistant Staphylococcus aureus Hypochloric acid isopropyl-β-d-thiogalactopyranoside Bacillithiol Catalytic domain Molecular dynamics dithiothreitol Sodium hypochlorite SiD MD simulations Formaldehyde Luria Bertani Methylglyoxal myeloperoxidase NADH NEM small colony variant nicotinamide adenine dinucleotide nicotinamide adenine dinucleotide phosphate H2O2 colony-forming unit Reactive chlorine species Reactive oxygen species

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The aldehyde dehydrogenase AldA contributes to the hypochlorite defense and is redox-controlled by protein S-bacillithiolation in Staphylococcus aureus

Authors

Marcel Imber, Vu Van Loi, Sylvia Reznikov, Verena Nadin Fritsch, Agnieszka J. Pietrzyk-Brzezinska, Janek Prehn, Chris Hamilton, Markus C. Wahl, Agnieszka K. Bronowska, Haike Antelmann,