| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8286891 | Redox Biology | 2017 | 45 Pages |
Abstract
Our results suggest for the first time that probucol ameliorates renal damage in DN by epigenetically suppressing p66Shc expression via the AMPK-SIRT1-AcH3 pathway.
Keywords
DAPIPASMMDASirtuin-1p66ShcNox2HbA1cAc-H3STZECMAMPKSirt1AMP-activated protein kinaseH&ENADPH oxidase 2ROSrenal injurystreptozotocinperiodic acid-Schiffchromatin immunoprecipitationIHCImmunohistochemistryNon-diabetic renal diseasetriglycerideEMTBUNdihydroethidiumFibronectinExtracellular matrixmalondialdehydeDiabetic nephropathyPASblood urea nitrogenhematoxylin-eosinGlycosylated hemoglobinDHEProbucolCHiPserum creatininetotal cholesterolHigh-glucoseReactive oxygen speciesSCR
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Authors
Shikun Yang, Li Zhao, Yachun Han, Yu Liu, Chao Chen, Ming Zhan, Xiaofen Xiong, Xuejing Zhu, Li Xiao, Chun Hu, Fuyou Liu, Zhiguang Zhou, Yashpal S. Kanwar, Lin Sun,