| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8288457 | Archives of Biochemistry and Biophysics | 2018 | 42 Pages |
Abstract
Effect of A53T α-syn overexpression and Fe exposure on neuronal lipid metabolism. A53T α-syn overexpression increased FAS expression levels, ACS activity and TAG content. A53T α-syn diminished ROS generation and lipid peroxidation induced by Fe-exposure. A53T α-syn cells exposed to Fe showed increased TAG content. The appearance of TAG in A53T α-syn cells could constitute a marker of neuronal injury during the early stages of PD.196
Keywords
FASTBATBARSMAGmonoacylglycerolα-SynHRPFFAPMSFFBSSDSDTTTBS-TCHOLACSPBSacyl-CoA synthetaseBSAMTTROSSDS–PAGEα-synucleinbovine serum albuminIronEDTAOleic acidThiobarbituric acidFatty acidFree fatty acidfatty acid synthaseParkinson's diseaseTriacylglycerolstriacylglycerolTAG یا triacylglycerols Oxidative stressdiacylglycerolsdichlorodihydrofluorescein diacetatedithiothreitolDAGsodium dodecyl sulphatefetal bovine serumphosphate buffer salinePhospholipidsphenylmethylsulfonyl fluoridelactate dehydrogenaseLDHLipid metabolismfatty acid methyl estersFAME یا fatty acid methyl esters thiobarbituric acid reactive substancesDopaminergic neuronsHorseradish peroxidasegas-liquid chromatographycholesterolReactive oxygen species
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Authors
SofÃa Sánchez Campos, Natalia P. Alza, Gabriela A. Salvador,