Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8288518 | Archives of Biochemistry and Biophysics | 2018 | 34 Pages |
Abstract
Raspberries are a rich source of ellagitannins and anthocyanins. The aim of this work was to investigate whether raspberry consumption can improve vascular function and to understand which phenolic metabolites may be responsible for the effects. A 3 arm double-blind randomized controlled crossover human intervention trial was conducted in 10 healthy males. Flow-mediated dilation (FMD) was measured at baseline, 2â¯h, and 24â¯h post-consumption of 200â¯g and 400â¯g of red raspberries containing 201 or 403â¯mg of total (poly)phenols, or a matched control drink. Raspberry (poly)phenol metabolites were analyzed in plasma and urine by UPLC-QTOF mass spectrometry using authentic standards. Significant improvements in FMD were observed at 2â¯h (1.6% (95%CI 1.2, 1.9) and 1.2% (95% CI 0.8, 1.5)) and 24â¯h (1.0% (95% CI 0.6, 1.2) and 0.7% (95%CI 0.2, 0.9)) post-consumption of the 200 and 400â¯g raspberry drinks as compared to control, respectively. Plasma ellagic acid, urolithin A-3-glucuronide and urolithin A-sulfate correlated with the improvements in FMD at 2 and 24â¯h post consumption, respectively. Consumption of dietary achievable amounts of red raspberries acutely improves endothelial function up to 24â¯h and ellagitannins may be responsible for the observed effect.
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Authors
Geoffrey Istas, Rodrigo P. Feliciano, Timon Weber, Rocio Garcia-Villalba, Francisco Tomas-Barberan, Christian Heiss, Ana Rodriguez-Mateos,