Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8288521 | Archives of Biochemistry and Biophysics | 2018 | 43 Pages |
Abstract
Calcium-mediated signaling and the functionality of Src-family tyrosine kinases (SFKs) are two interconnected processes. Activation of these kinases, which are coupled to a series of receptors, mediates Ca2+ mobilization by regulating Ca2+ channels, and the generated Ca2+ signal in turn exerts control on the kinase activity via calmodulin. In this review, we shall cover the regulation of selected processes where crosstalk between the functionality of SFKs and the Ca2+ signal occurs during the lifespan of the cell, when subjected to different extracellular or intracellular stimuli. These events result in the modulation of many physiological processes, which are essential to maintain organismal homeostasis. We discuss the importance of these mechanisms, and the implicated signaling pathways on essential cellular processes, comprising proliferation, differentiation, cell adhesion, migration, cytoskeletal remodeling, oocyte fertilization, apoptosis and autophagy. Thereafter, we discuss the role that Ca2+ and SFKs exert in the control of selected physiological functions, including hormones/neurotransmitters release, striated and smooth muscle contraction, glomerular filtration, stress response, and the cellular response to viral and bacterial infections.
Keywords
AMPKCREBEGFRPI3KEGFNFATBCRLRPmTORATFBMP-2RANKLICAM-1FAKHUVECDMBADGCpKaPMCAIκBIP3NMDAN-methyl-d-aspartateGPCRTRPV4HIF-1αRyRATGPKCAPAf-1IKKIP3RDISCcADPRFADDSFKSOCEPYK2CaSRNCAMNAADPFGFRIL-8PLA2CDC42RSVOPGPP2A23187p38MAPKTBK1CrkLMP2AASVSH2PP1TRAFTRPM7PIP3MLCKPAR-1SH3receptor activator of NFκB ligandGRB2Gab2MEGF10c-SrcSTIMNRKreceptor activator of NFκBGRB7Lamp-2aCa2+-sensing receptorCaMK-IIsarco(endo)plasmic reticulum Ca2+-ATPaseTNF1,2-bis(2-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid tetrakis(acetoxymethyl ester)lysosome-associated membrane protein type 2Ainhibitor of NFκBInositol 1,4,5-trisphosphate 3-kinasecyclic-ADP-riboseBDNFERK1/2IκB kinaseinositol-1,4,5-trisphosphateSrc-family kinasesMAPKNFκBSmall interfering RNAsiRNA[Ca2+]cytphospholipase A2Osteoprotegerinnicotinic acid adenine dinucleotide phosphateEBVInterleukin 8c-YesBAPTA-AMSykTANK-binding kinase 1cluster of differentiationSrc homology domain 2Src homology domain 3RankCAMSlatHuman umbilical vein endothelial cellCell signalingendoplasmic reticulumMIFGAPspleen tyrosine kinasehypoxia-inducible factor-1αepidermal growth factorapoptotic protease activating factor 1Macrophage migration inhibitory factorNuclear Factor of Activated T Cellstumor necrosis factor receptor-associated factorPlasma membrane Ca2+-ATPasecytosolic free Ca2+ concentrationBrain-derived neurotrophic factortumor necrosis factornuclear factor κBPhosphatasesphosphatidylinositol (3,4,5)-trisphosphatePhosphatidylinositol 3-kinaseactivating transcription factorSERCAstromal interaction moleculeintercellular adhesion molecule-1neural cell adhesion moleculemammalian target of rapamycinStore-operated calcium entryEpstein-Barr virusRous sarcoma virusavian sarcoma virusGTPase-activating proteinGrowth factor receptor bound protein 2autophagy-related proteinLow-density lipoprotein receptor-related proteinbone morphogenic protein-2cAMP response element-binding proteinprotein kinase AProtein kinase Cmitogen-activated protein kinaseDystrophin glycoprotein complexdeath-inducing signaling complexCalmodulinCa2+ channelsnormal rat kidneySrc-family kinaseMyosin light-chain kinaseAMP-activated kinaseEGF receptorIP3 receptorB-cell antigen receptorRyanodine receptorfibroblast growth factor receptorReceptorsProtease-activated receptor-1G protein-coupled receptor
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
EstefanÃa Anguita, Antonio Villalobo,