Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8288714 | Archives of Biochemistry and Biophysics | 2018 | 10 Pages |
Abstract
Here the phylogeny and physiological roles of representatives of this superfamily, their occurrence in all kingdoms of life, the relevant sequence motifs for definite identification and the available crystal structures are presented. We demonstrate the autocatalytic posttranslational maturation process and the impact of the covalent links on spectral and redox properties as well as on catalysis, including Compound I formation and reduction by one- and two-electron donors. Finally, we discuss the evolutionary advantage of these PTMs with respect to the proposed physiological functions of the metalloenzymes that range from antimicrobial defence in innate immunity to extracellular matrix formation and hormone biosynthesis.
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Authors
Andrea Nicolussi, Markus Auer, Benjamin Sevcnikar, Martina Paumann-Page, Vera Pfanzagl, Marcel Zámocký, Stefan Hofbauer, Paul G. Furtmüller, Christian Obinger,