Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8288997 | Archives of Biochemistry and Biophysics | 2017 | 37 Pages |
Abstract
The UbiX-UbiD system consists of the flavin prenyltransferase UbiX that produces prenylated FMN that serves as the cofactor for the (de)carboxylase UbiD. Recent developments have provided structural insights into the mechanism of both enzymes, detailing unusual chemistry in each case. The proposed reversible 1,3-dipolar cycloaddition between the cofactor and substrate serves as a model to explain many of the key UbiD family features. However, considerable variation exists in the many branches of the UbiD family tree.
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Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Stephen A. Marshall, Karl A.P. Payne, David Leys,