Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes

Graphic representation of hypothesis and results. We tested the hypothesis that the LKB1 complex associated with myofilament proteins in the sarcomere and altered this association with energy stress. In general, creatine kinase (CK) and adenylate kinase (AK) balance the available AT = P for use by the contractile proteins, specifically myosin. Pathological energy stress from FHC or CVD elevates myofibrillar AMP that recruits LKB1 and AMPK complex proteins to myofibrils. LKB1 activates AMPK in the presence of elevated AMP, which directly impacts myofilament function.320