| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8290500 | Archives of Biochemistry and Biophysics | 2013 | 8 Pages |
Abstract
- hPNMT operates by an ordered mechanism with AdoMet binding before norepinephrine.
- Epinephrine and AdoHcy both showed evidence of product inhibition.
- THIQ inhibitors compete with phenylethanolamine but are uncompetitive with AdoMet.
- Binding of AdoMet increased the binding affinity of the second substrate/inhibitor.
- log V/K pH profiles are all bell shaped with slopes of unity on each side.
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Authors
Qian Wu, Michael J. McLeish,