| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8290921 | Archives of Biochemistry and Biophysics | 2013 | 7 Pages |
Abstract
⺠Deletion of the P450 gene of Streptomyces coelicolor blocked sporulation and antibiotic synthesis. ⺠Purified recombinant P450 107U was used in a metabolomic screen, and glycocholic acid was identified as a substrate. ⺠P450 107U1 catalyzed the oxidation of the 7α-hydroxy group of glycocholic acid to a ketone.
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Authors
Zhenhua Tian, Qian Cheng, Francis K. Yoshimoto, Li Lei, David C. Lamb, F. Peter Guengerich,