Article ID Journal Published Year Pages File Type
8290969 Archives of Biochemistry and Biophysics 2012 7 Pages PDF
Abstract
► IL-6 destabilized atherosclerotic plaques in mice. ► IL-6 significantly downregulated P4Hα1 expression in HASMCs. ► IL-6 can activate the RAF-MEK1/2-ERK1/2 pathway. ► c-Jun mediated IL-6-induced P4Hα1 downregulation.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Interleukin 6 destabilizes atherosclerotic plaques by downregulating prolyl-4-hydroxylase α1 via a mitogen-activated protein kinase and c-Jun pathway
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