| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291104 | Archives of Biochemistry and Biophysics | 2012 | 7 Pages |
Abstract
⺠Combinations of anti-EGFR antibodies are reported to result in enhanced activity. ⺠Anti-EGFR biparatopic-SEED antibody was created with two different binding domains. ⺠Anti-EGFR biparatopic-SEED had enhanced combination-activity in a single molecule. ⺠Cross-linking two different epitopes is important for enhanced combination-activity.
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Authors
Christie Kelton, John S. Wesolowski, Maria Soloviev, Rene Schweickhardt, David Fischer, Emmi Kurosawa, Sean D. McKenna, Alec W. Gross,