Article ID Journal Published Year Pages File Type
8291123 Archives of Biochemistry and Biophysics 2012 7 Pages PDF
Abstract
► CaMKP was inactivated by oxidation with H2O2 or by alkylation with iodoacetamide. ► Oxidized CaMKP was reactivated by incubation with reducing agent 2-mercaptoethanol. ► Human CaMKP (hCaMKP) has three Cys residues, Cys-259, Cys-315 and Cys-359. ► A disulfide bond between Cys-359 and Cys-259/Cys-315 was formed upon oxidation. ► hCaMKP activity is reversibly regulated by oxidation/reduction at Cys-359.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Regulation of Ca2+/calmodulin-dependent protein kinase phosphatase (CaMKP) by oxidation/reduction at Cys-359
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