| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291146 | Archives of Biochemistry and Biophysics | 2012 | 9 Pages |
Abstract
⺠We studied N-homocysteinylation of ovine prion in vitro. ⺠Modification results in introduction of homocysteine to at least K197 and K207. ⺠Homocysteinylation leads to formation of aggregates about 1 μm. ⺠Homocysteinylation provokes an increase of content in beta-sheet content. ⺠Changes in physico-chemical properties indicate amyloid-like transformation.
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Authors
Yulia Y. Stroylova, Jean-Marc Chobert, Vladimir I. Muronetz, Hieronim Jakubowski, Thomas Haertlé,