| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291308 | Archives of Biochemistry and Biophysics | 2012 | 7 Pages |
Abstract
⺠LCAT penetration and acyl-enzyme formation determine enzyme activity in discoidal HDL. ⺠Cholesterol as a nucleophilic agent determines its esterification rate. ⺠Adjustment for phospholipid level is required to derive kinetic constants. ⺠Cholesterol influences the unfolding pattern of individual apoA-I domains. ⺠Substrate activation by apoA-I may include ester bond exposure to LCAT active center.
Keywords
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Biochemistry
Authors
Alexander D. Dergunov,