Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8291343 | Archives of Biochemistry and Biophysics | 2012 | 10 Pages |
Abstract
⺠A sensitive direct HPLC method is adapted to measure BH4 and its metabolites. ⺠The effect of oxidants on BH4 is determined and resulting metabolites measured. ⺠The primary product of BH4 autoxidation is BH2. ⺠The primary product of superoxide-catalyzed oxidation of BH4 is BH2. ⺠Hydroxyl radical driven BH4 oxidation results primarily in dihydroxanthopterin.
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Authors
Roberto Biondi, Giuseppe Ambrosio, Francesco De Pascali, Isabella Tritto, Enrico Capodicasa, Lawrence J. Druhan, Craig Hemann, Jay L. Zweier,