| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291376 | Archives of Biochemistry and Biophysics | 2012 | 7 Pages |
Abstract
⺠We developed a pure cell-free system of Nox2 with noncanonical cytosolic factors. ⺠The system consisted of recombinant Noxa1, Noxo1, Rac, and purified cytochrome b558. ⺠Using the system, we clarified the kinetic properties of Noxa1 in Nox2 activation. ⺠Noxa1 was a less potent activator of Nox2 than p67phox either with Noxo1 or p47phox. ⺠Noxa1 has remarkably lower affinity for the oxidase complex than p67phox.
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Authors
Masahito Kawano, Kazuhiro Miyamoto, Yuki Kaito, Hideki Sumimoto, Minoru Tamura,