| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291379 | Archives of Biochemistry and Biophysics | 2012 | 6 Pages |
Abstract
⺠The polyanion suramin is a human GIIA phospholipase A2 (hsPLA2GIIA) inhibitor. ⺠Single cationic residue mutants show increased or decreased suramin affinity. ⺠Altered suramin affinities correlate with intermolecular potential energy (IPE). ⺠Mutagenesis alters the conformation of the bound suramin to optimize the IPE. ⺠Molecules based on suramin can be used as novel hsPLA2GIIA inhibitors.
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Authors
Elisângela Aparecida Aragão, Davi Serradella Vieira, Lucimara Chioato, Tatiana Lopes Ferreira, Marcos Roberto Lourenzoni, Samuel Reghim Silva, Richard John Ward,