| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291393 | Archives of Biochemistry and Biophysics | 2012 | 11 Pages |
Abstract
⺠The Mycobacterium tuberculosis guaA gene encodes a homodimeric GMP synthetase (MtGMPS). ⺠The two-domain type MtGMPS exhibits positive homotropic cooperativity for XMP and NH4+. ⺠Mg2+ saturation curve is sigmoidal and there may be an additional binding site for this metal. ⺠Activity of ATPPase domain is independent of GATase domain. ⺠Substrate binding is random and PPi is the last product released.
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Authors
Tathyana Mar A. Franco, Diana C. Rostirolla, Rodrigo G. Ducati, Daniel M. Lorenzini, Luiz A. Basso, Diógenes S. Santos,