Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8291405 | Archives of Biochemistry and Biophysics | 2012 | 10 Pages |
Abstract
⺠In biological systems, Hg may exist as cysteine conjugates of CH3Hg and Hg2+. ⺠These conjugates [CH3Hg-S-Cys and Cys-S-Hg-S-Cys] resemble methionine and cystine. ⺠They are substrates for amino acid transporters and glutamine transaminase K. ⺠They are also potent inhibitors of cystathionine γ-lyase. ⺠Interaction of S-conjugates with transporters/enzymes may contribute to Hg toxicity.
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Authors
Christy C. Bridges, Boris F. Krasnikov, Lucy Joshee, John T. Pinto, André Hallen, Jianyong Li, Rudolfs K. Zalups, Arthur J.L. Cooper,