Article ID Journal Published Year Pages File Type
8291405 Archives of Biochemistry and Biophysics 2012 10 Pages PDF
Abstract
► In biological systems, Hg may exist as cysteine conjugates of CH3Hg and Hg2+. ► These conjugates [CH3Hg-S-Cys and Cys-S-Hg-S-Cys] resemble methionine and cystine. ► They are substrates for amino acid transporters and glutamine transaminase K. ► They are also potent inhibitors of cystathionine γ-lyase. ► Interaction of S-conjugates with transporters/enzymes may contribute to Hg toxicity.
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