Article ID Journal Published Year Pages File Type
8291529 Archives of Biochemistry and Biophysics 2011 8 Pages PDF
Abstract
► The effect of the antioxidant phenylaminoethyl selenide (PAESe) on doxorubicin (DOX)-mediated cardiotoxicity was determined. ► PAESe reduced evidence of DOX cardiotoxicity and weight loss in a prostate cancer xenograft model. ► PAESe reduced the formation of reactive oxygen species by DOX or by tert-butylhydroperoxide in human prostate cancer cells. ► PAESe did not decrease DOX antitumor activity in a prostate cancer xenograft model.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
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The antioxidant phenylaminoethyl selenide reduces doxorubicin-induced cardiotoxicity in a xenograft model of human prostate cancer
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