| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291568 | Archives of Biochemistry and Biophysics | 2011 | 9 Pages |
Abstract
⺠A raloxifene dimer metabolite was observed in CYP3A4 supersomeTM incubations. ⺠GSH products from HRP vs CYP3A4 suggested dimer was formed in the P450 active site. ⺠A dimer standard inhibited CYP3A4 activity towards 1' and 4 midazolam hydroxylase. ⺠Dimer formation was not affected by addition of ROS scavengers or trapping agents. ⺠Dimer formation was affected by addition of known CYP3A4 inhibitors/activators.
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Authors
John A. Davis, Robert J. Greene, Sean Han, Dan A. Rock, Larry C. Wienkers,