Article ID Journal Published Year Pages File Type
8291572 Archives of Biochemistry and Biophysics 2011 5 Pages PDF
Abstract
► Guanine binds to a DPCPX-sensitive receptor in proximal tubule basolateral membrane. ► Guanine promotes the activation of Gi protein leading to a decrease in cAMP level. ► Guanine decreases Na+-ATPase activity in isolated basolateral membrane. ► These events indicate a role of guanine on the modulation of renal sodium excretion.
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Life Sciences Biochemistry, Genetics and Molecular Biology Biochemistry
Preview
Guanine-induced inhibition of renal Na+-ATPase activity: Evidence for the involvement of the Gi protein-coupled receptor
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