Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8291590 | Archives of Biochemistry and Biophysics | 2011 | 5 Pages |
Abstract
⺠Merozoite surface protein 2 (MSP2), a malaria surface antigen, forms amyloid-like fibrils in solution. ⺠EGCG disaggregates pre-formed MSP2 fibrils into soluble oligomers. ⺠EGCG remodels MSP2 fibrils by altering the β-sheet-like structure of the fibrils. ⺠Other flavonoids, such as baicalein and resveratrol, do not disaggregate MSP2 fibrils.
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Authors
Indu R. Chandrashekaran, Christopher G. Adda, Christopher A. MacRaild, Robin F. Anders, Raymond S. Norton,