| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291599 | Archives of Biochemistry and Biophysics | 2011 | 7 Pages |
Abstract
⺠Genipin induces ho-1 gene expression via an Nrf2 pathway, a mechanism in which oxidative stress is not involved. ⺠JNK1/2 mediates phosphorylation and nuclear translocation of Nrf2 in response to genipin. ⺠JNK1/2 is a downstream effector of PI3-kinase in genipin signaling leading to HO-1 induction. ⺠HO-1 mediates the genipin-mediated suppression of LPS-induced expression of iNOS and COX-2 in murine macrophages.
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Authors
Woo-Kwang Jeon, Hey-Young Hong, Byung-Chul Kim,