Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8291624 | Archives of Biochemistry and Biophysics | 2011 | 7 Pages |
Abstract
⺠Human DUOX1 cannot substitute for DUOX2 in thyroid hormone synthesis. ⺠DUOX2 like DUOX1, yields a protein that does not co-purify with heme. ⺠DUOX2 peroxidase-like domain is more structurally stable than that of DUOX1. ⺠Heme titrations show both DUOX peroxidase-like domains bind heme weakly. ⺠Tighter heme binding may require interaction with a protein partner such as DUOXA2.
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Authors
Jennifer L. Meitzler, Paul R. Ortiz de Montellano,