| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291652 | Archives of Biochemistry and Biophysics | 2011 | 10 Pages |
Abstract
⺠Chlorinated HDL promotes expression of heme oxygenase-1 (HO-1) in endothelial cells. ⺠Expression involves p42/44 MAPK and activation of transcription factor Egr-1. ⺠EMSA demonstrates induction of Egr-1 DNA binding activity. ⺠Immunocytochemistry shows translocation of Egr-1 to the nucleus. ⺠Silencing of p42/44 MAPK and Egr-1 impairs HO-1 expression to baseline levels.
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Authors
Christine Rossmann, Anamaria Rauh, Astrid Hammer, Werner Windischhofer, Sandra Zirkl, Wolfgang Sattler, Ernst Malle,