| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291740 | Archives of Biochemistry and Biophysics | 2011 | 7 Pages |
Abstract
⺠Harmine inhibits DYRK1A by competing against ATP. ⺠The V306A mutation in the ATP-binding pocket renders partial harmine resistance to DYRK1A. ⺠DYRK1A V306A mutant is fully functional in the presence of physiological concentrations of ATP. ⺠A model of harmine and DYRK1A interactions is proposed.
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Authors
Tatyana Adayev, Jerzy Wegiel, Yu-Wen Hwang,