| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291772 | Archives of Biochemistry and Biophysics | 2011 | 8 Pages |
Abstract
⺠Mitochondrial m-calpain large subunit localizes mainly in the mitochondrial outer membrane (OM). ⺠Free calpain small subunits are present in the mitochondrial intermembrane space. ⺠OM-bound calpains are activated by calpain small subunit, Grp75, and ATP. ⺠Free calpain small subunit releases the OM-bound m-calpain in the presence of Grp75, ATP, and Ca2+. ⺠Release of m-calpain from the OM has an important implication in facilitating apoptosis.
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Authors
Taku Ozaki, Tetsuro Yamashita, Sei-ichi Ishiguro,