| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291829 | Archives of Biochemistry and Biophysics | 2011 | 9 Pages |
Abstract
⺠We demonstrate that the expression of Mdm2 is diminished in nrf2-deleted MEFs. ⺠Nrf2 directly involves in the regulation of the basal expression of Mdm2 through the antioxidant response element. ⺠p53 protein was accumulated in nrf2-deleted MEFs. ⺠In human ovarian cancer cells, Nrf2 inhibition by shRNA increased p53 signaling to enhance cell death in response to hydrogen peroxide treatment.
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Authors
Aram You, Chang-won Nam, Nobunao Wakabayashi, Masayuki Yamamoto, Thomas W. Kensler, Mi-Kyoung Kwak,