| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8291867 | Archives of Biochemistry and Biophysics | 2011 | 8 Pages |
Abstract
⺠Wild-type sterol C24-methyltransferase for the first time from any source - Candida albicans - has been purified and characterized. ⺠Turnover number of CaSMT established to be 0.01sâ1. ⺠Sterol biosynthesis inhibitors that target sterol C24-methyltransferase have been evaluated in vitro and in vivo. ⺠Ergosterol but not cholesterol or sitosterol shown to be an allosteric modulator of sterol C24-methyltransferase activity.
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Authors
Kulothungan Ganapathy, Ragu Kanagasabai, Thi Thuy Minh Nguyen, W. David Nes,