Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8291891 | Archives of Biochemistry and Biophysics | 2011 | 11 Pages |
Abstract
⺠High concentration of glucose augmented palmitate-induced INS-1 cell death. ⺠Level of TCA cycle intermediates was declined in HG/PA-treated INS-1 cell. ⺠Stimulators of fatty acid oxidation protected HG/PA-induced INS-1 cell death. ⺠Supplement of TCA cycle intermediates protected HG/PA-induced INS-1 cell death. ⺠Knockdown of glutamate dehydrogenase augmented glucolipotoxicity. ⺠Knockdown of mitochondrial tricarboxylate carrier attenuated glucolipotoxicity.
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Authors
Sung-E Choi, Youn-Jung Lee, Geum-Sook Hwang, Joo Hee Chung, Soo-Jin Lee, Ji-Hyun Lee, Seung Jin Han, Hae Jin Kim, Kwan-Woo Lee, Youngsoo Kim, Hee-Sook Jun, Yup Kang,