| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8292342 | Biochemical and Biophysical Research Communications | 2018 | 8 Pages |
Abstract
Exosomes are nano-vesicles released by tumor cells to modulate extracellular environment. Accumulating evidence revealed that glioblastoma derived exosomes contain multiple pro-angiogenic factors to induce the proliferation of endothelial cells. Here, we investigated the role of GBM-derived exosomes in inducing the permeability of the blood-brain barrier. We found that VEGF-A was over-expressed in hypoxic GBM-derived exosomes, which enhance the permeability of a BBB in vitro model by interrupting the expression of claudin-5 and occludin. In vivo permeability assay showed hypoxic GBM-derived exosomes remained functional in the blood circulation and induced the permeability of BBB.
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Authors
Chen Zhao, Hongyan Wang, Chenghao Xiong, Yu Liu,